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MEASSuRE – MEA stretching, recording and imaging

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  • MEASSuRE: Integrates cytostretching, electrophysiology, and imaging.
    Enables in vitro research mirroring in vivo conditions.
  • Facilitates reproducible study of mechanical stretch effects on tissue electrophysiology.
  • Features exclusive stretchable microelectrodes (sMEA) from BMSEED.
  • Offers three modules for independent and concurrent cell stretching, imaging, and electrophysiology.
  • For more details visite BMSEED’s website.
Category:

Module description

Mechanics Module

  • radial, linear
  • custom strain fields
  • one fast impulse stretch or cyclical stretch
  • up to 50% strain
  • up to 75/s strain rate
  • any stretch pattern
  • high reproducibility

Imaging Module

  • before, during and after stretching
  • up to 2,000 frames per second at 2MP resolution
  • custom software to independently measure the tissue strain

Electrophysiology Module

  • electrodes stretch with the cells/tissue
  • recording/stimulation before, during, and after stretching
  • comparison of cell health and function pre and post stretch
  • soft MEAs on elastomeric substrates
  • standard rigid MEAs are also available

Model comparison

MEASSuRE-Mini

  • Mechanics Module:
    • strain rate up to 1/s, strain up to 20%
    • can be used in an incubator
  • Imaging Module:
    • frame rate: 150fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Physiological Stretch
    • Tissue engineering, regenerative medicine
    • Organ-on-a-Chip, pre-clinical drug development
    • Mechanobiology

MEASSuRE-Premium

  • Mechanics Module:
    • strain rate up to 50/s, strain up to 50%
  • Imaging Module:
    • frame rate: 2,000 fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Pathological Stretch
    • Traumatic brain injury (TBI), repeated concussions
    • Spinal cord injury (SCI)
    • Neurodegenerative diseases
    • Muscle injuries

MEASSuRE-X

  • Mechanics Module:
    • strain rate up to 75/s, strain up to 50%
  • Imaging Module:
    • frame rate: 2,000 fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Pathological Stretch
    • Traumatic brain injury (TBI), repeated concussions
    • Spinal cord injury (SCI)
    • Neurodegenerative diseases
    • Muscle injuries

ABOUT

Micro Electrode Array  Stretching Stimulation und Recording Equipment

MEASSuRE represents a comprehensive plug-and-play instrumentation system, seamlessly integrating three distinct laboratory methodologies: (1) a cell stretching apparatus, (2) a data acquisition system tailored for electrophysiological studies, and (3) a live cell imaging component. This innovative system expands the horizons of in vitro research by facilitating experiments that mimic in vivo conditions, particularly in terms of the mechanical and electrical milieu surrounding cells.

MEASSuRE empowers researchers to systematically investigate the impact of both physiological and pathological mechanical stretching on the electrophysiological properties of biological tissues with high reproducibility and reliability. The development of stretchable microelectrodes, exclusive to BMSEED, has been instrumental in realizing the full potential of MEASSuRE for in vitro electrophysiology studies

Module description

Module description

Mechanics Module

  • radial, linear
  • custom strain fields
  • one fast impulse stretch or cyclical stretch
  • up to 50% strain
  • up to 75/s strain rate
  • any stretch pattern
  • high reproducibility

Imaging Module

  • before, during and after stretching
  • up to 2,000 frames per second at 2MP resolution
  • custom software to independently measure the tissue strain

Electrophysiology Module

  • electrodes stretch with the cells/tissue
  • recording/stimulation before, during, and after stretching
  • comparison of cell health and function pre and post stretch
  • soft MEAs on elastomeric substrates
  • standard rigid MEAs are also available

Model comparison

Model comparison

MEASSuRE-Mini

  • Mechanics Module:
    • strain rate up to 1/s, strain up to 20%
    • can be used in an incubator
  • Imaging Module:
    • frame rate: 150fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Physiological Stretch
    • Tissue engineering, regenerative medicine
    • Organ-on-a-Chip, pre-clinical drug development
    • Mechanobiology

MEASSuRE-Premium

  • Mechanics Module:
    • strain rate up to 50/s, strain up to 50%
  • Imaging Module:
    • frame rate: 2,000 fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Pathological Stretch
    • Traumatic brain injury (TBI), repeated concussions
    • Spinal cord injury (SCI)
    • Neurodegenerative diseases
    • Muscle injuries

MEASSuRE-X

  • Mechanics Module:
    • strain rate up to 75/s, strain up to 50%
  • Imaging Module:
    • frame rate: 2,000 fps
  • Electrophysiology Module:
    • 2×60 channels
  • Applications: Pathological Stretch
    • Traumatic brain injury (TBI), repeated concussions
    • Spinal cord injury (SCI)
    • Neurodegenerative diseases
    • Muscle injuries

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