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BA-01M – Bridge Amplifier Module

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Intracellular Bridge Mode Amplifier

  • Precise current clamp performance
  • Easy to use cell penetration mode with sharp microelectrodes
  • Compatible with any data acquisition system
  • Also available as 19″ stand-alone device
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About BA-01M

The bridge amplifier module BA-01M is a wide bandwidth high impedance intracellular amplifier for recordings with sharp microelectrodes or suction (patch) pipettes. Currently, BA amplifiers are used in vertebrate (rat, mouse, cat, fish etc.) and invertebrate (leech, crab, snail, insect etc.) neurons, muscle cells, other excitable tissue and plant cells.

The BA-01M EPMS module has the same specification as the BA-01X 19″ stand-alone device except that it has only one current input range (1 nA/V), only one potential output (x10 mV), only one bridge balance range (0-1000 MΩ) and no oscillation shut-off.

Bridge amplifiers are also available as 19″ stand-alone devices.

Features

  • True current clamp operation with measured membrane potential and complete cancellation of series resistance
  • Can be used with sharp microelectrodes, and patch pipettes in the whole-cell and perforated-patch configuration
  • Digital DISPLAYS for current, voltage and electrode resistance
  • OSCILLATION SHUT-OFF unit prevents cells from damage
  • BUZZ and ELECTRODE CLEAR facility
  • Digital setting of gated stimulus amplitude, setting and digital read-out of holding current
  • Now with enhanced (x10) current range for electroporation and iontophoresis

Combine with

  • EXT-10C (extracellular amplifier module)
  • DPA-2FX (amplifier/filter module)
  • ISO-STIM 01M (stimulus isolator module)
  • TMR-02M (timer module)

and get a complete system for stimulating, extracellular and intracellular recording in one 19” rackmount cabinet

Technical Data

Headstage

Input voltage range: ±1 V
Operating voltage: ±15 V
Enclosure: Size: 23 x 70 x 26 mm, grounded
Dovetail: Size: 70 mm x 17 mm x 3 mm
Electrode connector: BNC with driven shield
REF connector: SMB connector
Ground connector: 2.4 mm connector
Input resistance (CC): >1013 Ω (internally adjustable)
Current range: ±10 nA max. (100 MΩ feedback, X1 CURRENT RANGE)
±100 nA max. (100 MΩ feedback, X10 CURRENT RANGE)

Electrode parameter controls

OFFSET: range ±200 mV, ten-turn control
CAPACITY COMPENSATION: range 0 – 30 pF, ten-turn control
BIAS: range ±200 pA, ten-turn control
BRIDGE BALANCE: 0-100 MΩ (range switch set to 10 MΩ)
0-1000 MΩ (range switch set to 100 MΩ)
adjustable with ten-turn control
Electrode clear circuit: Application of max. DC currents (-Imax or +Imax)
Cell penetration: BUZZ, duration ~2.5 – ~100 ms

Electrode resistance test

Sensitivity 1 mV / MΩ application of square current pulses ±1 nA
Display: 3 ½ digit, XXX MΩ, activated by key switch
(same as POTENTIAL display)

Bandwidth and speed response (CC mode, optimal capacity compensation)

Full power bandwidth (REL = 10 kΩ): >10 kHz
rise time (10% – 90%), square pulse, 1 V pp 40 µs (voltage), 30 µs (current) (REL = 100 MΩ)
25 µs (voltage and current) (REL = 5 MΩ)

Outputs

Output impedance: 50 Ω
Max. voltage: ±12 V
Current output: BNC connector, sensitivity 0.1 V/nA,
Current display: 3 ½ digits, XX.XX nA, resolution 10 pA (X1 CURRENT RANGE)
3 ½ digits, XXX.X nA, resolution 100 pA (X10 CURRENT RANGE)
POTENTIAL OUTPUT: BNC connector, sensitivity 10 V/V
Potential output resolution in AC: 50 µV

Digital display:

Display mV/MΩ 3 ½ digits, XXXX mV or XXX MΩ
Display current 3 ½ digits, XX.XX nA (X1 CURRENT RANGE)
3 ½ digits, XXX.X nA (X10 CURRENT RANGE)

Inputs

Input impedance analog 100 kΩ
Input range ±12 V
Input impedance digital (TTL) 10 kΩ
Input range TTL 0-5 V
Current stimulus input CC via BNC connectors
X1 CURRENT RANGE: 1 nA/V
X10 CURRENT RANGE: 10 nA/V
Holding current: X1 CURRENT RANGE: ±10 nA
X10 CURRENT RANGE: ±100 nA
Adjustable with ten-turn control
Step gate input via BNC connector (TTL)
Gated stimulus CC X1 CURRENT RANGE: resolution: 10 pA, range: ±10 nA
X10 CURRENT RANGE: resolution: 100 pA, range: ±100 nA
with digital control of current step size
Polarity selectable with toggle switch

Physical specifications

Dimensions: Module for EPMS-07 system
width: 2 U
Power requirements: Supply power is provided by EPMS-07

Downloads

Manual BA-01M manual
Brochure BA-Series

 

About BA-01M

About BA-01M

The bridge amplifier module BA-01M is a wide bandwidth high impedance intracellular amplifier for recordings with sharp microelectrodes or suction (patch) pipettes. Currently, BA amplifiers are used in vertebrate (rat, mouse, cat, fish etc.) and invertebrate (leech, crab, snail, insect etc.) neurons, muscle cells, other excitable tissue and plant cells.

The BA-01M EPMS module has the same specification as the BA-01X 19″ stand-alone device except that it has only one current input range (1 nA/V), only one potential output (x10 mV), only one bridge balance range (0-1000 MΩ) and no oscillation shut-off.

Bridge amplifiers are also available as 19″ stand-alone devices.

Features

Features

  • True current clamp operation with measured membrane potential and complete cancellation of series resistance
  • Can be used with sharp microelectrodes, and patch pipettes in the whole-cell and perforated-patch configuration
  • Digital DISPLAYS for current, voltage and electrode resistance
  • OSCILLATION SHUT-OFF unit prevents cells from damage
  • BUZZ and ELECTRODE CLEAR facility
  • Digital setting of gated stimulus amplitude, setting and digital read-out of holding current
  • Now with enhanced (x10) current range for electroporation and iontophoresis

Combine with

  • EXT-10C (extracellular amplifier module)
  • DPA-2FX (amplifier/filter module)
  • ISO-STIM 01M (stimulus isolator module)
  • TMR-02M (timer module)

and get a complete system for stimulating, extracellular and intracellular recording in one 19” rackmount cabinet

Technical Data

Technical Data

Headstage

Input voltage range: ±1 V
Operating voltage: ±15 V
Enclosure: Size: 23 x 70 x 26 mm, grounded
Dovetail: Size: 70 mm x 17 mm x 3 mm
Electrode connector: BNC with driven shield
REF connector: SMB connector
Ground connector: 2.4 mm connector
Input resistance (CC): >1013 Ω (internally adjustable)
Current range: ±10 nA max. (100 MΩ feedback, X1 CURRENT RANGE)
±100 nA max. (100 MΩ feedback, X10 CURRENT RANGE)

Electrode parameter controls

OFFSET: range ±200 mV, ten-turn control
CAPACITY COMPENSATION: range 0 – 30 pF, ten-turn control
BIAS: range ±200 pA, ten-turn control
BRIDGE BALANCE: 0-100 MΩ (range switch set to 10 MΩ)
0-1000 MΩ (range switch set to 100 MΩ)
adjustable with ten-turn control
Electrode clear circuit: Application of max. DC currents (-Imax or +Imax)
Cell penetration: BUZZ, duration ~2.5 – ~100 ms

Electrode resistance test

Sensitivity 1 mV / MΩ application of square current pulses ±1 nA
Display: 3 ½ digit, XXX MΩ, activated by key switch
(same as POTENTIAL display)

Bandwidth and speed response (CC mode, optimal capacity compensation)

Full power bandwidth (REL = 10 kΩ): >10 kHz
rise time (10% – 90%), square pulse, 1 V pp 40 µs (voltage), 30 µs (current) (REL = 100 MΩ)
25 µs (voltage and current) (REL = 5 MΩ)

Outputs

Output impedance: 50 Ω
Max. voltage: ±12 V
Current output: BNC connector, sensitivity 0.1 V/nA,
Current display: 3 ½ digits, XX.XX nA, resolution 10 pA (X1 CURRENT RANGE)
3 ½ digits, XXX.X nA, resolution 100 pA (X10 CURRENT RANGE)
POTENTIAL OUTPUT: BNC connector, sensitivity 10 V/V
Potential output resolution in AC: 50 µV

Digital display:

Display mV/MΩ 3 ½ digits, XXXX mV or XXX MΩ
Display current 3 ½ digits, XX.XX nA (X1 CURRENT RANGE)
3 ½ digits, XXX.X nA (X10 CURRENT RANGE)

Inputs

Input impedance analog 100 kΩ
Input range ±12 V
Input impedance digital (TTL) 10 kΩ
Input range TTL 0-5 V
Current stimulus input CC via BNC connectors
X1 CURRENT RANGE: 1 nA/V
X10 CURRENT RANGE: 10 nA/V
Holding current: X1 CURRENT RANGE: ±10 nA
X10 CURRENT RANGE: ±100 nA
Adjustable with ten-turn control
Step gate input via BNC connector (TTL)
Gated stimulus CC X1 CURRENT RANGE: resolution: 10 pA, range: ±10 nA
X10 CURRENT RANGE: resolution: 100 pA, range: ±100 nA
with digital control of current step size
Polarity selectable with toggle switch

Physical specifications

Dimensions: Module for EPMS-07 system
width: 2 U
Power requirements: Supply power is provided by EPMS-07

Downloads

Downloads

Manual BA-01M manual
Brochure BA-Series

 

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